self-avoidance

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  • Self-avoidance has been widely discussed amongst scientists and throughout time the experiments were done in several animal models.
  • Numerous models and structures with different development timing and life cycles are used in studies of self-avoidance.
  • Based on these data, Dscam results in a lack of self-avoidance of sister dendrites.
  • Thus, the self-recognizing mechanism would be useful not only to self-avoidance but also as a means of individualization.
  • The clear conclusion of the study was that continuity between all parts of the neuron is critical for self-avoidance to operate.
  • By contrast, co-expression of complementary isoforms within the same neuron restored self-avoidance.
  • Hence, dendrites of the same neuron spread out by avoiding one another (self-avoidance).
  • These results lead to the conclusion that Dscam1 diversity is not required in individual neurons for self-avoidance.
  • Contrarily to the first hypothesis, the second would require the continuity and communication between all parts of the cell for self-avoidance to occur.
  • The initial idea was that, in some early development point, neural cells contact with each other and organize their distribution, but several studies demonstrated that self-avoidance is also present in adult life.
  • Thus, two phyla appear to have recruited different molecules to mediate similar, complex strategies for self-recognition, thereby promoting self-avoidance.
  • In the late 1990s and beyond, model organisms started to be used in the studies and the molecular mechanisms of self-avoidance started to be unraveled.
  • Dscam interaction stimulates self-avoidance mechanisms that are essential for normal neural circuit development.
  • Timeline regarding important discoveries about neuronal self-avoidance.
  • These data establish that recognition between Dscam1 isoforms on opposing surfaces of neurites of the same cell provides the molecular basis for self-avoidance.
  • Self-avoidance ensures that there is no overlap of isoneural branches and is at the basis of neuronal circuit assembly.
  • The correct innervation is due to repulsive nature of interactions between these movement detector neurites reinforcing all the anterior models of self-avoidance.
  • Self-avoidance is necessary to prevent extensive overlapping in the aborization pattern and to facilitate the coverage of the neuronal processes across different regions of the nervous system during development.
  • The members of the protocadherin gene cluster were compelling candidates to provide the molecular code required for the maintenance of the self/non-self discrimination that led to self-avoidance.
  • This was further explored, by other authors, the fact that this self-avoidance would require neurites to be able to distinguish between self and non-self, reinforcing the ideas of Yau.
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