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  • The dosage instructions also show that risedronate can be taken with less water than other drugs in the class.
  • Risedronate has also been shown to reduce the risk of hip fractures.
  • Therefore, it is recommended that risedronate be taken with the body upright, and followed by a glass of water.
  • Risedronate has a faster esophageal transit time and different chemical chain which results in less gastrointestinal side-effects than other drugs in this class.
  • Risedronate treatment has been demonstrated to help restore bone mass in osteopenia/osteoporosis associated with Graves' disease.
  • Rheumatologic symptoms can be improved by treatment with biphosphonates, such as pamidronate or risedronate.
  • For those with osteoporosis but who have not had any fractures evidence does not support a reduction of in fracture risk with risedronate or etidronate.
  • Risedronate is taken orally, usually weekly or monthly.
  • Notably, if risedronate lodges in the esophagus, it can lead to esophageal ulcers.
  • In 2006, P&G faced controversy over its handling of clinical research involving risedronate (News Reports and discussion).
  • Moreover, risedronate is poorly absorbed when taken with food, so it is recommended that no food or drink other than water be taken for 2 hours before and 30 minutes after taking risedronate.
  • In a trial of children with mild OI, oral risedronate increased bone mineral densities, and reduced nonvertebral fractures.
  • Risedronate is also available as a 75 mg tablet to be taken on two consecutive days each month (2CDM) in order to optimize patient adherence.
  • In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate (Merck) and risedronate.
  • In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the jaw, often preceded by dental procedures inducing trauma to the bone.
  • Etidronate has the same disadvantage as pyrophosphate in inhibiting mineralization, but all of the potent N-containing bisphosphonates including Alendronate and also risedronate, ibandronate, and zoledronate, do not.
  • In vitro studies have shown that Rab GGTase can be inhibited by nitrogen-containing bisphosphonate drugs such as risedronate; however, the effects of such drugs seem to be much more limited in vivo (Coxon).
  • Certain drugs like alendronate, etidronate, risedronate, raloxifene and strontium ranelate can be helpful for the preventing of osteoporotic fragility fractures in postmenopausal women with osteoporosis.
  • Risedronic acid (INN) or risedronate sodium (USAN) is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
  • Commonly used drugs are bisphosphonates including alendronate, risedronate, and ibandronate; selective estrogen receptor modulators (SERMs) such as raloxifene; estrogen; calcitonin; and teriparatide.