pioneer axon

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  • Info Pioneer axon is the classification given to axons that are the first grow in a particular region. more...
  • Several theories relating to the structure and function of pioneer axons are currently being explored.
  • In addition, pioneer axons can act as guidepost cells to more distant pioneer neurons.
  • These cells are essential in providing navigational information to pioneer axons.
  • The mechanisms of pioneer axons and their role in axon guidance is currently being explored.
  • Instead, the pioneer axons assumed alternate configurations and followed different trajectories.
  • Furthermore, it has been shown that Robo plays a diversified role in pioneer axon guidance in different areas of the brain during embryonic development.
  • The role of pioneer axons in neuronal development has been studied extensively in various invertebrate and vertebrate systems in both the central nervous system and peripheral nervous system.
  • The resulting trajectories are due to pioneer axons growing from guidepost to guidepost cells.
  • The second is that pioneer axons are no different from follower axons, and that they play no role in guiding follower axons.
  • The first theory is that pioneer axons are specialized structures, and that they play a crucial role in guiding follower axons.
  • In addition, without the guidepost cells, the pioneer axons did not find the stereotyped route that pioneer axons would normally navigate.
  • A single chemotactic cue can both act as an attractant or repellent to pioneer axons, and may work from either a distance or within the immediate vicinity.
  • Although these experiments have shed light on the functions of the pioneer axons, the results reveal conflicting information into the extent of the effect of pioneer axons on proper development.
  • In later stages of limb growth, axons from more distal neurons fasciculate with these pioneer axons.
  • In particular, glial cells demonstrate an interaction with the growth cones of pioneer axons.
  • Netrins primarily function as attractions of pioneer axons towards the midline.
  • A variety of chemotactic cues provide essential signaling directing the directional growth of pioneer axons.
  • Although pioneer axons and follower axons both possess growth cones, there are several morphological differences related to the function of pioneer axons.
  • There is even a study in zebrafish with results showing that, when pioneer axons are eliminated, they can be replaced by follower axons, which since then behave like pioneer ones.