in axon

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  • It has been shown that glial cells also play a role in axon guidance in various ways.
  • Guidepost cells are identified by their singular importance in axon guidance of other cells.
  • He continued to research the properties of nervous systems throughout his life, most recently focusing on ion dynamics in axon cytoskeleton.
  • This process is required for efficiency in growth and for signals in axon orientation.
  • Therefore, this class of molecules has both a cell-cell adhesion role and a cell-surface receptor role, in axon navigation.
  • They were first discovered in Drosophila, through a mutant screen for genes involved in axon guidance.
  • The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.
  • Wnt is also involved in the dorsal-ventral formation of the central nervous system through its involvement in axon guidance.
  • The mechanisms of pioneer axons and their role in axon guidance is currently being explored.
  • Much of the early work in axon guidance was done in the grasshopper, where individual motor neurons were identified and their pathways characterized.
  • This upregulation implies that peripherin may also play a role in axon regeneration.
  • However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation.
  • Netrins are a class of proteins involved in axon guidance.
  • Remarkably, the majority of the tracts formed, indicating that other factors play a role in axon guidance that can correct for the loss of pioneer neurons.
  • At the same time, it is worth noting that in most cases pioneer neurons do not contain unique characteristics and their role in axon guidance can be substituted by other neurons.
  • Ephrin-B also contains a PDZ binding motif important in axon guidance regulation via G-protein signaling.
  • This caused focus to shift to DCC's role in axon guidance for a time, until one study implicated DCC in regulation of cell death.
  • This cytokine, called osteopontin, may be able to aid in axon regeneration by exposing its integrin receptor binding sites.
  • NUDEL is also known to play a role in axon regeneration and has an additional DISC1-modulated function as a cysteine endopeptidase.
  • The binding of Slit to any member of the Roundabout receptor family results in axon repelling through changes in the axon growth cone.
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