hairy cell leukemia

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  • Info Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. more...
  • Men are four to five times more likely to develop hairy cell leukemia than women.
  • Decision to treat Patients with hairy cell leukemia who are symptom-free typically do not receive immediate treatment.
  • Despite decade-long remissions and years of living very normal lives after treatment, hairy cell leukemia is officially considered an incurable disease.
  • The best clinical success has been achieved in treating patients with refractory hairy cell leukemia.
  • Aleukemia can occur in any of the four major types of leukemia, and is particularly common in hairy cell leukemia.
  • The cause of hairy cell leukemia is not known, but it is no longer believed to be related to viral infections.
  • As with many cancers, the cause of hairy cell leukemia is unknown.
  • An antigen characteristic of hairy cell leukemia cells is expressed on certain activated B cells.
  • Between regularly scheduled appointments, people who have hairy cell leukemia should report any health problems, especially viral or bacterial infections, as soon as they appear.
  • However, peripheral neuropathy has been reported occasionally after repeated doses of cladribine in the treatment of hairy cell leukemia.
  • It is also possible to definitively diagnose hairy cell leukemia through flow cytometry on blood or bone marrow.
  • ANXA1 protein expression is specific to hairy cell leukemia.
  • However, two variants have been described: Hairy cell leukemia-variant, which usually is diagnosed in men, and a Japanese variant.
  • While survivors of solid tumors are commonly declared to be permanently cured after two, three, or five years, people who have hairy cell leukemia are never considered 'cured'.
  • For hairy cell leukemia, cladribine can be given by i.v. infusion or subcutaneous (s.c.) injection.
  • John Moore first visited UCLA Medical Center on October 5, 1976, after learning he had hairy-cell leukemia.
  • The Hairy Cell Leukemia Consortium was founded in 2008 to address researchers' concerns about the long-term future of research on the disease.
  • Cladribine is an anti-neoplastic agent used in the treatment of hairy cell leukemia; its mechanism of action is inhibition of adenosine deaminase.
  • Pentostatin is used to treat hairy cell leukemia.
  • It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells.
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