distal convoluted tubule

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  • Info The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting duct system.
  • Much of the ion transport taking place in the distal convoluted tubule is regulated by the endocrine system.
  • The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule.
  • Use of carbenicillin can cause hypokalemia by promoting potassium loss at the distal convoluted tubule of the kidney.
  • They form in the distal convoluted tubule and collecting ducts of nephrons, then dislodge and pass into the urine, where they can be detected by microscopy.
  • Each distal convoluted tubule delivers its filtrate to a system of collecting ducts, the first segment of which is the connecting tubule.
  • This cell membrane protein participates in the control of ion homeostasis at the distal convoluted tubule portion of the nephron.
  • Since Ca 2+ is actively reabsorbed in the distal convoluted tubule, loop diuretics generally do not cause hypocalcemia.
  • In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal convoluted tubule.
  • In the presence of parathyroid hormone, the distal convoluted tubule reabsorbs more calcium and secretes more phosphate.
  • It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule.
  • Atrial natriuretic peptide causes the distal convoluted tubule to secrete more sodium.
  • Specifically, the LGR5 +ve stem cells contribute into the formation of the thick ascending limb of Henle's loop and the distal convoluted tubule.
  • Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels.
  • By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss.
  • Like the structurally related thiazide diuretics, xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule.
  • It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule.
  • Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule.
  • Inorganic fluoride inhibits adenylate cyclase activity required for antidiuretic hormone effect on the distal convoluted tubule of the kidney.
  • Macula densa cells are located in the distal convoluted tubule, and stimulate juxtaglomerular cells to release renin when they detect a drop in sodium concentration in tubular fluid.
  • The ascending limb drains urine into the distal convoluted tubule.
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