axonemal

All Adjective Noun
29 examples (0.03 sec)
  • Axonemal dynein facilitates the movement of cilia and flagella, and cytoplasmic dynein facilitates transport of intracellular cargos.
  • Dynein intermediate chain 2, axonemal, also known as axonemal dynein intermediate chain 2, is a protein that in humans is encoded by the DNAI2 gene.
  • The IFT machinery is organized in two structural complexes - A and B. These complexs are involved in the coordinated movement of macromolecular cargo from the basal body along axonemal microtubules to the cilium tip and back again.
  • Polyglycylation is a form of posttranslational modification of glutamate residues of the carboxyl-terminal region tubulin in certain microtubules (e.g., axonemal) originally discovered in Paramecium, and later shown in mammalian neurons as well.
  • These include motor proteins, such as myosin, which is responsible for muscle contraction, kinesin, which moves cargo inside cells away from the nucleus along microtubules, and dynein, which produces the axonemal beating of motile cilia and flagella.
  • Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.
  • Intraflagellar transport (IFT), the process by which axonemal subunits, transmembrane receptors, and other proteins are moved up and down the length of the flagellum, is essential for proper functioning of the flagellum, in both motility and signal transduction.
  • However, the Cornell researchers suggest that some of the axonemal vesicles were directly shipped from the IS through the connecting cilium as SARA was detected in the connecting cilium and basal body, possibly serving as an adaptor protein participating in rhodopsin's translocation.
  • It is proposed that the assembly of tektin heteropolymers produces filaments with repeats of 8, 16, 24, 32, 40, 48 and 96 nm, generating the basis for the complex spatial arrangements of axonemal components.