axon pathfinding

7 examples (0.02 sec)
  • It plays an important role in ocular motor axon pathfinding.
  • Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development.
  • This protein is considered a crucial component of the axon and presynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.
  • Guidance molecules serve to control axon pathfinding through repulsion, and also initiate pruning of exuberant synaptic connections.
  • Axon pathfinding is the process by which neurons follow very precise paths, sends out axons, and react to specific chemical environments to reach the correct endpoint.
  • Semaphorins, which are short range inhibitory proteins that act as axonal growth cone guidance molecules, are synthesized by neurons during axon pathfinding.
  • Robo receptors have also been shown to be crucial regulators of many other axon pathfinding decisions during development, including the projection of retinal axons in the optic tract, and of olfactory axons in the olfactory epithelium.