axon guidance

77 examples (0.02 sec)
  • Info Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach the correct targets. more...
  • It has been shown that glial cells also play a role in axon guidance in various ways.
  • Guidepost cells are identified by their singular importance in axon guidance of other cells.
  • However, understanding the molecular and cellular biology of axon guidance would not begin until decades later.
  • Several types of axon pathways have been extensively studied in model systems to further understand the mechanisms of axon guidance.
  • Heparin sulphate is believed to also be present during neural growth as a type of co-factor for axon guidance.
  • They were first discovered in Drosophila, through a mutant screen for genes involved in axon guidance.
  • The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.
  • The mechanisms of pioneer axons and their role in axon guidance is currently being explored.
  • Much of the early work in axon guidance was done in the grasshopper, where individual motor neurons were identified and their pathways characterized.
  • It is a cell-type dependent axon guidance factor.
  • Septins are also involved in cell migration and axon guidance in C.elegans.
  • Furthermore, it has been shown that Robo plays a diversified role in pioneer axon guidance in different areas of the brain during embryonic development.
  • Genetics and biochemistry have identified a large set of molecules that affect axon guidance.
  • Axon guidance directs the initial wiring of the nervous system and is also important in axonal regeneration following an injury.
  • Netrins are axon guidance molecules that transmit their activity through 2 different receptors.
  • Netrins are a class of proteins involved in axon guidance.
  • Remarkably, the majority of the tracts formed, indicating that other factors play a role in axon guidance that can correct for the loss of pioneer neurons.
  • At the same time, it is worth noting that in most cases pioneer neurons do not contain unique characteristics and their role in axon guidance can be substituted by other neurons.
  • Ephrin-B also contains a PDZ binding motif important in axon guidance regulation via G-protein signaling.
  • Another key function of XMAP215 in microtubule dynamics is in the regulation of axon guidance.
  • Next »

How axon guidance gets used