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  • These same reports stated that the FDA had failed to find evidence of aminopterin in the wheat gluten.
  • One such medium that is commonly used is HAT medium, which contains hypoxanthine, aminopterin and thymidine.
  • Leucovorin has been used in rats, dogs and humans to rescue aminopterin toxicity.
  • The New York State Food Laboratory reported that aminopterin was found in samples sent to them by Cornell.
  • The selective culture medium is called HAT medium because it contains hypoxanthine, aminopterin, and thymidine.
  • Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s.
  • Farber was able to use a drug of this type, aminopterin, to achieve a temporary remission in childhood leukemia.
  • Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.
  • When a similar cluster of abnormalies appears in the absence of exposure to antifolates it is referred to as aminopterin-like syndrome without aminopterin.
  • This medium is supplemented with hypoxanthine, aminopterin and thymidine, hence the name HAT medium.
  • Although the use of aminopterin as a rodenticide is widely asserted on the web and elsewhere, there is no evidence that it has ever been used for that purpose either in the United States or elsewhere in the world.
  • Aminopterin is widely used in selection media (such as HAT medium) for cell culture, particularly in the development of hybridomas, which secrete monoclonal antibodies.
  • Similar congenital abnormalities have been documented with methotrexate, and collectively their teratogenic effects have become known as the fetal aminopterin syndrome.
  • Aminopterin was discontinued by Lederle Laboratories in favor of methotrexate due to manufacturing difficulties of the former.
  • Aminopterin is illegal in China, and neither Cornell University nor the FDA could replicate the New York lab's results.
  • Aminopterin in the medium blocks the de novo pathway.
  • On 23 March, the New York State Food Laboratory reported that aminopterin was found in samples sent to them by Cornell.
  • In contrast, animals given aminopterin in an amount of 0.041 mg/kg/day x 6 days without folic acid died.
  • The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic index in a rodent tumor model.
  • Animal studies published in 1956 showed the therapeutic index of methotrexate was better than that of aminopterin, and clinical use of aminopterin was thus abandoned in favor of methotrexate.
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