amino acid substitutions

47 examples (0.04 sec)
  • A third possibility is that the amino acid substitution makes little or no positive or negative difference to the affected protein.
  • This change was produced by two amino acid substitutions, which prevent binding of the second hormone.
  • For each form of MODY, multiple specific mutations involving different amino acid substitutions have been discovered.
  • More modern approaches use directed evolution to screen for amino acid substitutions that enhance glycosynthase activity.
  • This successful modification prompted the further creation of analogs with additional amino acid substitutions.
  • A position of a codon is said to be a non-degenerate site if any mutation at this position results in amino acid substitution.
  • The amino acid substitutions between species were seen therefore to be neutral or not impactful to the function of the protein.
  • People with one of these improper amino acid substitutions also have the skipping mutation.
  • Two amino acid substitutions distinguish the human FOXP2 protein from that found in chimpanzees, but only one of these two changes is unique to humans.
  • Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension.
  • This mutation and other amino acid substitutions alter the enzyme's structure, reducing or abolishing its activity.
  • If it occurs in an important structural area or in the active site, one amino acid substitution may inactivate or substantially change the functionality of the protein.
  • Resistance to rimantadine can occur as a result of amino acid substitutions at certain locations in the transmembrane region of M2.
  • NNRTI resistance has been linked to over 40 amino acid substitutions in vitro and in vivo.
  • A single amino acid substitution, and in particular a single nucleotide substitution, is responsible for an activating mutation.
  • Two major forces drive the amino-acid substitution rates away from uniformity: substitutions occur with the different frequencies, and lessen functionally tolerated than others.
  • Three amino acid substitutions were inadvertently introduced in the subunits used for the original structure and a subsequent structure determination using the correct sequences demonstrated the same overall structure except for a few significant changes around the active site.
  • The resultant single amino acid substitution in this transport protein, by a mechanism yet to be determined, causes the elimination of pheomelanin expression seen in the white tiger.
  • The three copies within the gene have different binding partners, due to amino acid substitutions within the PSD-95 protein and its ligands.
  • Amino acid substitutions in OXA enzymes can also give the ESBL phenotype.
  • Next »