The completely consistent and logical nature of the defense mechanism, namely encapsulation of the penetrating fragment in connective tissue so that the tissue movements driving fragment movement are effectively minimized and peristalsis-driven migration of the fragment is thereby prevented.The AFT model, while first developed to describe mechanical failure, has been applied frequently to biological and medical situations.In most toxicological models, the effect is proportional to concentration of toxin or amount of insult.…

Hazard ratios can prove harder to explain in layman's terms.The log-logistic distribution provides the most commonly used AFT model.Unlike the Weibull distribution, it can exhibit a non-monotonic hazard function which increases at early times and decreases at later times.…

In most toxicological models, the effect is proportional to concentration of toxin or amount of insult.However, in the AFT model, both effect (abortion) and the time to effect are dependent on concentration.This statistical model fit MRLS data which showed abortions occurred rapidly and in in higher frequencies at high doses of ETCs, and the onset of abortions was delayed and abortions occurred with lower frequency at low doses.…

In the statistical area of survival analysis, an accelerated failure time model (AFT model) is a parametric model that provides an alternative to the commonly used proportional hazards models.Whereas a proportional hazards model assumes that the effect of a covariate is to multiply the hazard by some constant, an AFT model assumes that the effect of a covariate is to accelerate or decelerate the life course of a disease by some constant.…

The Weibull distribution (including the exponential distribution as a special case) can be parameterised as either a proportional hazards model or an AFT model, and is the only family of distributions to have this property.The results of fitting a Weibull model can therefore be interpreted in either framework.…

In the statistical area of survival analysis, an accelerated failure time model (AFT model) is a parametric model that provides an alternative to the commonly used proportional hazards models.Whereas a proportional hazards model assumes that the effect of a covariate is to multiply the hazard by some constant, an AFT model assumes that the effect of a covariate is to accelerate or decelerate the life course of a disease by some constant.This is especially appealing in a technical context where the 'disease' is a result of some mechanical process with a known sequence of intermediary stages.…